New NICE guidance: genetic testing now recommended before Clopidogrel
New NICE guidance: genetic testing now recommended before Clopidogrel
Award-winning PGx testing · Registered with the MHRA · UKCA marked
One saliva sample, 47 individual genetic tests. Find out which medicines are likely to work for you, and which may cause side effects. Ordered online, done at home, and useful for the rest of your life.
Research-backed
Free UK delivery
Results in 4–6 weeks
NICE-aligned
Your data stays private
12 genes · 78 medicines
One test, results for life
Recommended by NICE for Clopidogrel
AWARD-WINNING · REGISTERED WITH THE MHRA · UKCA MARKED
START HERE · THREE QUICK ANSWERS
Three questions people ask before they order. The short answers are here, and the detail is one click away.
Care matched to you, not the average patient. Instead of trial and error, your clinician chooses medicines and doses using information about your own body, including your genes.
Personalised medicine
PGx looks at the genes that control how your body processes medicines. One saliva sample shows which of 78 common medicines are likely to work well for you, and which may cause side effects.
Pharmacogenomics · PGx
Founded by UK doctors, registered with the MHRA and built on the PREPARE-UPGx trial. 12 genes, 47 variants, 78 medicines, and only recommendations your clinician can act on.
Award-winning · UK doctors
01 · WHY WOULD I NEED A TEST?
Up to 90% of common medicines only work well for 30–50% of the people who take them. Often, the reason is written in your genes.
Source: Spear BB et al., Trends in Molecular Medicine, 2001; NHS England Genomics.
Around 1 in 3 people process some statins slowly, so the drug builds up and causes pain or fatigue. A different statin, or a different dose, may suit you better.
Cholesterol · Statins
Your genes affect how quickly your body clears many antidepressants. Too fast and they don’t work; too slow and side effects build up.
Anxiety · Depression
About 30% of people carry a variant that makes Clopidogrel less effective. NICE now recommends a genetic test before it is prescribed.
Stroke · Heart
THE EVIDENCE
Every Mantara report follows the protocol tested in the PREPARE trial: 6,930 patients in 7 European countries, published in The Lancet in 2023.
6,930
patients in 7 European countries took part in the trial
30%
fewer serious side effects with genotype-guided prescribing in the trial
MHRA
registered, and CE and UKCA marked in the UK
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02 · IS MY MEDICINE COVERED?
Type the name of a medicine you take. We’ll show whether the Mantara PGx Panel Test gives your clinician guidance on it, and which gene is involved.
Popular searches
Can’t see your medicine? Contact us. The panel grows as new evidence becomes clinically actionable.
03 · HOW DOES IT WORK?
No needles, no clinic visit. Just 1 ml of saliva, collected at home.
01
Kits arrive in 2–3 working days. Order before midday and we dispatch the same day.
02
Collect a small saliva sample, register your kit online, and post it back in the prepaid envelope.
03
Our specialist partner laboratory in Germany analyses 12 of your genes, including 47 alleles, to understand how your body may respond to 78 different medicines.
04
A clear, personalised report is emailed securely within 4–6 weeks, ready to share with your GP or consultant.
04 · WHAT WILL MY REPORT TELL ME?
Every medicine gets a plain-English verdict and a dose note your clinician can act on. No gene jargon unless you want it.
Your genotype, what it means for you, and a clear recommendation for each of 78 medicines, grouped by condition.
Swipe to see the full table →
Atorvastatin
Cholesterol
SLCO1B1 · *1/*1
Use as normal
Simvastatin
Cholesterol
SLCO1B1 · *5/*5
Increased side-effect risk · consider alternative
Clopidogrel
Stroke prevention
CYP2C19 · *2/*2
Poor metaboliser · alternative recommended
Sertraline
Depression · anxiety
CYP2C19 · *2/*2
Consider lower starting dose
Omeprazole
Acid reflux
CYP2C19 · *1/*1
Use as normal
12
CYP2B6
CYP2C9
CYP2C19
CYP2D6
CYP3A5
DPYD
F5
HLA-B
SLCO1B1
TPMT
UGT1A1
VKORC1
WHY 12 GENES AND 47 VARIANTS?
The 12 genes are the ones with the strongest evidence for changing how the body processes medicines, as tested in the PREPARE-UPGx trial. Within those genes we check 47 specific variants (alleles), each one linked to a clinically actionable recommendation from the Dutch Pharmacogenetics Working Group (DPWG). Every variant is a separate test, which is why one saliva sample equals 47 individual tests.
12
genes from the PREPARE-UPGx panel, published in The Lancet (2023)
47
variants (alleles), each with DPWG-actionable guidance
78
medicines, only those with clinically actionable evidence
Mental health · Heart & circulation · Pain · Digestion · Diabetes · Cancer · HRT & oestrogens. Only medicines with actionable PGx evidence.
A plain-English summary for you, and a referenced clinical section for your GP or consultant.
Genes don’t change. Your report stays valid for every future prescription, and we update guidance as evidence evolves.
See exactly what you get before you order: a real report, anonymised.
05 · WHICH TEST DO I NEED?
Most people choose the full panel. The rapid Clopidogrel test is taken by a healthcare professional, so we guide you to one of our partner clinicians.
MOST POPULAR · BUY ONLINE
£429
one-off · or 3 × £143 with Klarna
The complete picture: 12 genes, 78 commonly prescribed medicines across mental health, heart & circulation, pain, digestion, diabetes, cancer and HRT.
At-home saliva sample, free UK delivery
Results in 4–6 weeks, useful for life
Clear report to share with your GP or consultant
Registered with the MHRA · CE & UKCA marked
NEW · VIA A HEALTHCARE PROFESSIONAL
Results in days
cheek swab, taken by a clinician
A fast, focused test for anyone taking Clopidogrel, after a stroke, heart attack or stent, in line with NICE 2024 guidance. The swab must be taken by a healthcare professional, so choose your route:
I’m a patient → we connect you with a partner clinician near you
I’m a clinician, pharmacist or nurse → order directly for your patients
CYP2C19 is also covered in the PGx Panel Test (a different test, slightly different variants)
PARTNER FINDER
Prefer to test through a clinician, or need the rapid Clopidogrel test? Every partner is a verified GMC, NMC or GPhC registrant who offers Mantara testing, and can take your sample in clinic.
YOUR DATA
Your personal details and your genetic data are kept in separate systems, linked only by a randomly generated code.
Encrypted in transit and at rest, to strict UK GDPR standards.
We only check the gene variants that affect medicines.
Your genetic data is never shared or sold. You decide who sees your report.
Figures from NHS England, NICE and peer-reviewed studies.
1 in 20
hospital beds in the UK are occupied because of an adverse drug reaction
£2.2bn
the estimated annual cost of adverse drug reactions to the NHS
~30%
fewer clinically significant adverse reactions when prescribing is guided by PGx
30–50%
of patients respond well to the most common medicines. The rest are guessing
06 · WHY CHOOSE MANTARA?
Mantara Health was founded by UK doctors who believe every patient deserves truly personalised care. Our panel is deliberately focused: only genes and medicines with the strongest, clinically actionable evidence make the cut.
A far more complete picture than tests that look at one or two genes.
Only medications backed by the strongest, clinically actionable PGx evidence.
Encrypted, UK GDPR-compliant, and never shared with industry partners.
Registered with the MHRA and manufactured to rigorous quality standards.
REAL PATIENTS · CONSENTED REVIEWS
Statins · Cholesterol
“I was taking statins but started experiencing muscle pain and fatigue. The test showed I’m a poor metaboliser of the statin I’d been prescribed. My doctor switched me to one that suits my genetic profile, and I manage my cholesterol without the horrible side effects.”
Ms S, Cotswolds
Verified Mantara customer
Pain relief · Post-surgery
“After surgery the usual painkillers weren’t helping much. The test found I’m a poor metaboliser of certain opioids, no wonder they weren’t working. My doctor switched me to something more suitable and the difference was huge.”
Mr B, Oxford
Verified Mantara customer
Antidepressants · Mental health
“I’d struggled with side effects from several antidepressants. The test identified that I metabolise some drugs too quickly and others too slowly. With that insight my doctor changed my medication and I finally feel more stable.”
Mr M, Somerset
Verified Mantara customer
Rated Excellent · Google Reviews
FOR GPs, CONSULTANTS, PHARMACISTS & CLINICS
Clinically actionable recommendations from the Dutch Pharmacogenetics Working Group (DPWG), the same protocol used in the UPGx study published in The Lancet, plus a rapid CYP2C19 pathway for patients on Clopidogrel.
Peer-reviewed evidence pack and CPD-style clinician guide
Bulk ordering, monthly reconciliation and a partner portal (coming)
Practice pricing for kits you stock, with lab fees invoiced only when a sample is registered
Registered with the MHRA. Members of BIVDA, CERSI-PGx and the IPN. Send an EDTA blood sample or take saliva in clinic.
07 · STILL GOT QUESTIONS?
Still unsure? Book a free 10-minute call with one of our team. No pressure, no jargon.
It helps most if you take medicine for a long-term condition, have had side effects before, or want to know which medicines are likely to work for you. It does not cover every medicine, so your clinician can help you decide.
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FREE 10-MINUTE CALL
Tell us a little about your medicines and we’ll call you back at a time that suits. Clinicians: use the same form and we’ll route you to our clinical team.
Mon–Fri, 9:00–17:30
The Grainger Suite, Dobson House, Regent Centre, Newcastle upon Tyne NE3 3PF
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